투고논문
| JKMRS Volume 26, No 1, pp 17, High-pressure NMR application fo... | |
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| 2022년 03월 20일 / 조회수: 715 | |
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High-pressure NMR application for amyloid-beta peptides Jin Hae Kim* Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Republic of Korea Received Mar 19, 2022; Revised Mar 20, 2022; Accepted Mar 20, 2022 Abstract: High-pressure (HP) NMR is a versatile tool to investigate diverse features of proteins. This technique has been particularly powerful to elucidate structural dynamics that only populates sufficiently in a pressurized condition. Amyloidogenic proteins, which are prone to aggregate and form amyloid fibrils, often maintains highly dynamic states in its native or aggregation-prone states, and HP NMR contributed much to advance our understandings of the dynamic behaviors of amyloidogenic proteins and the molecular mechanisms of their aggregation. In this mini review, we therefore summarize recent HP NMR studies on amyloid-beta (Aβ), the representative amyloidogenic intrinsically disordered protein (IDP). Keywords: high-pressure NMR, amyloid-beta, protein aggregation, protein dynamics, NMR spectroscopy * Address correspondence to: Jin Hae Kim, Department of New Biology, Daegu Gyeongbuk Institute of Science &Technology, Daegu 42988, Republic of Korea, Tel: 82-53-785-1770; E-mail: jinhaekim@dgist.ac.kr |
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| 첨부파일 | 3_KimJH.pdf |