투고논문

Abstract
Benzo[a]pyrene (BaP), one of the polycyclic aromatic hydrocarbons (PAHs), is an endocrine disruptor and carcinogenic. This study was conducted to investigate the metabolic changes of zebrafish short-term exposure to BaP using nuclear magnetic resonance (NMR) spectroscopy. In our results, the multivariate analysis showed that the metabolic responses were differed according to the exposure concentration. Also, it was observed that exposure to high concentration of BaP (162 μg/L and 1620 μg/L) increased the levels of creatine, histidine, and inosine in zebrafish, which means high concentration of BaP exposure affected the energy metabolism and immune function in zebrafish.

Keywords zebrafish, benzo[a]pyrene, PAHs, metabolomics, NMR

* Address correspondence to: Suhkmann Kim, Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241, Republic of Korea, Tel: 82-51-510-2240; Fax: 82-51-516-7421; E-mail: suhkmann@pusan.ac.kr