투고논문
| JKRMS Volume 28, No 4, pp 60, Metabolomic Analysis of Daphnia ... | |
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| 2024년 12월 20일 / 조회수: 209 | |
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Metabolomic Analysis of Daphnia magna Exposed to Fluoxetine Using HR-MAS NMR Hyemin Kim, Seonghye Kim, Sujin Lee, Sojeon Moon, Jihwan Park, Gisu Park and Suhkmann Kim* Department of Chemistry, Pusan National University, Busan, 46241, Republic of Korea Received Dec 19, 2024; Revised Dec 20, 2024; Accepted Dec 20, 2024 Abstract Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), enhances serotonin levels in synapses to alleviate depressive symptoms. This study investigates the effects of fluoxetine on the aquatic organism Daphnia magna (D. magna), known for its environmental sensitivity. D. magna was exposed to 100 µg/L of fluoxetine for 72 hours, and metabolomic changes were examined using high-resolution magic angle spinning (HR-MAS) NMR. A total of twenty-eight metabolites were identified. Compared to the control group, fluoxetine exposure resulted in decreased levels of phenylalanine and increased levels of sn-glycero- 3-phosphocholine, inosine, proline, carnosine, and tryptophan. Keywords HR-MAS NMR, Metabolomics, D. magna, Fluoxetine *Address correspondence to: Suhkmann Kim, Department of Chemistry, Chemistry Institute for Functional Materials, Pusan National University, Busan 46241, Republic of Korea; Tel: 82-51-510-2240; Fax: 82-51-516-7421; E-mail: suhkmann@pusan.ac.kr |
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| 첨부파일 | 6. JKMRS_KimSM_pp60-63.pdf |