투고논문

Abstract Nuclear magnetic resonance (NMR) spectroscopy is a versatile tool for investigating various physicochemical properties of biomolecules. Among diverse applications of biomolecular NMR spectroscopy, ¹⁹F-based methodology has recently attracted much attention from researchers in protein science owing to its advantageous applicability to proteins of high molecular weights or heterogeneous structural states. In this mini-review, the recent application example of ¹⁹F NMR to transthyretin, a representative amyloidogenic protein, thus being an important yet challenging target for structural investigation, is summarized along with some perspectives for its future directions.

Keywords NMR spectroscopy, fluorine, ¹⁹F NMR, transthyretin, protein aggregation

* Address correspondence to: Jin Hae Kim, Department of New Biology, Daegu Gyeongbuk Institute of Science &Technology, Daegu 42988, Republic of Korea, Tel: 82-53-785-1770; E-mail: jinhaekim@dgist.ac.kr